What you’ll learn:

• GLP-1 medications can lead to significant weight loss.  
• GLP-1s offer benefits beyond weight loss, like improving blood sugar control and promoting heart health.
• GLP-1s are being studied for their potential for managing other health issues like dementia, kidney disease, fatty liver disease, sleep apnea, and addiction. 

You’ve probably heard the buzz around Ozempic and its popularity as a weight loss solution. Ozempic is part of a growing class of medications called GLP-1 receptor agonists. Originally developed to treat diabetes, these medications have recently gained fame for their weight management benefits. (Ozempic can be prescribed off-label for weight loss.) The truth is diabetes management and weight loss are just two of the things GLP-1 medications can treat. Exciting studies show that they might offer a range of potential health benefits beyond the numbers on the scale.

Heart and brain health, kidney and liver function, polycystic ovary syndrome (PCOS), and even addiction are just a few of the conditions they might treat in the future. When combined with personalized support, like Noom’s program, GLP-1 medications can be a powerful tool for long-term health, not just weight loss.

Let’s explore how these medications work, their various health benefits, and how they can be part of a comprehensive approach to overall health improvement. 

If you’re ready to find out if one is right for you, see if you qualify for Noom Med. We’ll pair you with a qualified clinician to discuss the options. 

What is a GLP-1 medication?

GLP-1 medications mimic a hormone called GLP-1 that your body naturally makes when you eat. This hormone is in charge of controlling your appetite and blood sugar levels. By mimicking the GLP-1 hormone, these medications tap into your body’s natural signals to help reduce hunger and increase feelings of fullness. 

These medications include popular brand names like Weogvy (semaglutide), Zepbound (tirzepatide), and Saxenda (liraglutide). While they each have different active ingredients, they all work to regulate blood sugar and make you feel less hungry. They have been used successfully to treat type 2 diabetes and promote weight loss.

What are the most popular GLP-1 medications?

There are many different GLP-1 medications. While they all work similarly, they each have different features and costs. Your healthcare provider can work with you to weigh the various advantages and disadvantages of each medication to help you choose the right one for you. The chart below highlights some of the most popular GLP-1 medication options:

Medication	Brand names and uses	Cost per month (without insurance)
Semaglutide – GLP-1 receptor agonist that helps regulate appetite and calorie intake	Wegovy (FDA-approved for weight loss  and to reduce the risk of heart disease) Ozempic (FDA-approved for diabetes management, off-label for weight loss) Rybelsus (FDA-approved for diabetes management, off-label for weight loss)	$969- $1,350
Tirzepatide – GLP-1 and GIP receptor agonist that helps regulate appetite and calorie intake.	Zepbound (FDA-approved for weight loss)Mounjaro (FDA-approved for diabetes management, off-label for weight loss)	$1,060- $1,070
Liraglutide – GLP-1 receptor agonist that helps regulate appetite and calorie intake	Saxenda (FDA-approved for weight loss) Victoza (FDA-approved for diabetes management and to reduce risk of heart disease, off-label for weight loss)	$800- $1,400
Exenatide – GLP-1 receptor agonist that regulates blood sugar	Byetta (FDA-approved for diabetes management, off-label for weight loss) Bydureon BCise (FDA-approved for diabetes management, off-label for weight loss)	$880-$1005
Dulaglutide – GLP-1 receptor agonist that regulates blood sugar	Trulicity (FDA-approved for diabetes management and to reduce risk of heart disease, off-label for weight loss)	$977

How GLP-1 medications aid weight loss

One of the most popular uses for GLP-1 medications is weight loss. These medications are highly effective at reducing hunger and helping people lose significant amounts of weight.

Here’s how these clever meds help you lose some weight:

• Stomach slowdown: They put the brakes on how quickly your stomach empties, so you stay satisfied for longer after meals.
• Reduce appetite and curb cravings: They work on your brain’s reward centers, reducing hunger and making you feel more content with what you’ve eaten.

But remember, while these meds can be a big help, they work best when paired with a healthy lifestyle. That’s where Noom comes in. We’ll help you build sustainable habits, track your food and movement, and support you every step of the way to reach your goals.

How long does it typically take to see results from GLP-1 medications?

Now, for the big question: when can you expect to see results? While everyone is unique, most people notice changes within the first few weeks of starting a GLP-1 medication. 

But don’t get discouraged if the scale doesn’t move right away! It can take up to 12 weeks for many to see the effects. Remember, these medications are often started at lower doses and gradually increased, which means the results will build up over time.

Are GLP-1 medications suitable for everyone looking to lose weight?

GLP-1 medications aren’t for everyone. They can only be prescribed for weight loss for people with BMIs of 30 or above, or those with a BMI of 27 or above who also have weight-related health issues. 

Your healthcare provider can help determine whether these medications are right for you based on your health needs and goals. If you qualify, Noom Med will pair you with a qualified clinician who can find the right GLP-1 for you. 

How GLP-1 medications help manage type 2 diabetes

GLP-1 medications aren’t just for weight loss but also for managing blood sugar levels. As mentioned, they were originally developed to treat type 2 diabetes. Some of these medications have been helping people control their blood sugar for about two decades, long before their weight loss potential was realized. Here’s how they work:

• Regulate insulin: They stimulate your pancreas to release insulin when your blood sugar rises, helping to bring those levels back down. 
• Slow digestion: The slower digestion time helps with weight loss and prevents rapid spikes in blood sugar after meals. 

How effective are GLP-1 medications for blood sugar control?

While the performance of the individual medication will vary, studies show they can lower your A1C by a significant 0.8% to 1.9%. This is a big deal in managing diabetes and keeping complications at bay.

Can GLP-1 medications replace other diabetes treatments?

While GLP-1 medications are effective at managing blood sugar, they aren’t always a solo act. 

In some cases, they might be effective enough on their own, especially for those with milder type 2 diabetes. But more often, they team up with other diabetes treatments like metformin or insulin for optimal blood sugar control. GLP-1 medications work particularly well when combined with other treatments, creating a synergistic effect. A doctor will need to approve any combinations.

Of course, a healthy diet and regular exercise are still important for managing diabetes. GLP-1 medications aren’t a free pass to ditch those healthy habits. It’s all about finding the right balance and creating a personalized plan that works for you, like we do at Noom.

Are there any special considerations for using GLP-1 medications for blood sugar control?

Keep an eye on your blood sugar levels while using GLP-1 medications. These medications can sometimes lead to low blood sugar (hypoglycemia), especially if you’re taking other diabetes medications. But don’t worry—your healthcare provider will keep you in the loop on how to adjust your treatment and what to watch out for.

How GLP-1 medications aid heart health

GLP-1 medications aren’t just about weight loss and blood sugar control—they may also have significant benefits for your heart health. Let’s explore how these medications can support your cardiovascular well-being.

How do GLP-1 medications help improve heart health?

Studies have shown that these meds can reduce the risk of major adverse cardiovascular events (MACE for short) in people with type 2 diabetes.

How do GLP-1 medications benefit heart health?

Now, this is where it gets really interesting. GLP-1 medications can benefit your heart in several ways:

• Blood sugar regulation: GLP-1 medications help maintain stable blood sugar levels, reducing the risk of heart disease associated with diabetes.
• Blood pressure reduction: These medications can contribute to lower blood pressure, decreasing the strain on your heart and lowering the risk of hypertension-related heart problems.
• Cholesterol management: They aid in lowering LDL (bad) cholesterol levels, which helps prevent plaque buildup in the arteries, promoting better cardiovascular health.
• Weight loss: GLP-1 medications support weight loss, which can reduce the overall burden on the heart, improve heart function, and decrease the risk of obesity-related heart issues.
• Cardioprotective effects: Research suggests that GLP-1 medications may directly protect heart tissues, improving heart muscle function and reducing the risk of heart failure. Research suggests that these medications can actually enhance the health of your heart muscle. 
• Reduction of inflammation: These medications may also help decrease inflammation in the body, which is a known factor in the development of cardiovascular diseases.

Are all GLP-1 medications equally effective for heart health?

Here’s the thing—while many GLP-1 medications show heart health benefits, they’re not all created equal. For example, the FDA has approved Wegovy (which contains semaglutide) to reduce the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and weight-related issues. Victoza (liraglutide) and Trulicity (dulaglutide) have also been approved for similar purposes. Your healthcare provider can help determine which medication might be best for your specific needs. It’s all about finding the right fit for you.

Other potential GLP-1 medication benefits

Hold onto your hats because we’re about to explore some exciting new frontiers in GLP-1 medication research. While these drugs are well-known for their effects on weight loss, blood sugar control, and heart health, scientists are discovering even more ways they might benefit your overall health. Let’s take a look at some of these promising areas:

• Kidney health: GLP-1 medications may help protect your kidneys. Research shows that people taking semaglutide, a type of GLP-1 medication, had a 24% lower chance of experiencing major kidney problems compared to those taking a placebo. This could be great news for people at risk of kidney disease.
• Liver function: Some GLP-1 medications being developed might improve liver health. This could be especially helpful for people with conditions like fatty liver disease, which is often linked to obesity and diabetes.
• Brain health: There’s growing interest in how GLP-1 medications might affect the brain. Some researchers are looking into whether these drugs could help with conditions like dementia or Alzheimer’s disease. While it’s too early to say for sure, the potential is exciting.
• Polycystic ovary syndrome (PCOS): GLP-1 medications might help manage PCOS, a hormonal disorder that can affect fertility and metabolism. More studies are still needed, but early results look promising.
• Addiction: New research has shown some promise for semaglutide in treating alcohol use disorder and other substance use disorders. However, the research is still in the preliminary phases, and more trials will need to be conducted to determine whether these medications could be approved for addiction treatment.
• Sleep apnea: A study suggests that GLP-1 receptor agonists could also help manage sleep apnea by promoting significant weight loss and improving metabolic and inflammatory issues.

While these potential benefits are exciting, many are still being studied. More research is needed to fully understand how GLP-1 medications might help with these conditions. Drug companies are currently developing 27 new GLP-1 drugs that could offer additional health benefits beyond weight loss and diabetes management.

As scientists continue to explore the full potential of GLP-1 medications, it’s clear that these drugs might have even more to offer than we initially thought. Always talk with your healthcare provider about the latest research and whether GLP-1 medications might be right for you.

Side effects of GLP-1 medications

Alright, let’s talk about the side effects. While GLP-1 medications can be super effective for weight loss and managing blood sugar levels, it’s important to go in with your eyes wide open. Here’s the scoop on what you might experience:

What are the most common side effects of GLP-1 medications?

Let’s start with the most common side effects. These are the ones you’re most likely to experience, especially when you first start taking the medication or increase the dosage:

• Nausea
• Vomiting
• Diarrhea
• Constipation

Some people may also experience headaches, dizziness, or fatigue. 

Now, before you get too worried, here’s some good news: These side effects tend to improve as your body adjusts to the medication.

Can GLP-1 medications cause more serious effects?

While rare, more serious adverse effects can occur. Here’s the important part: if you experience any of these issues, contact your healthcare provider immediately.  Here’s what to watch out for:

• Pancreatitis: Symptoms include abdominal pain that may radiate to your back, nausea, vomiting, and fever.
• Gallbladder problems: Signs can include abdominal pain (especially in the upper right side), fever, nausea, or jaundice (yellowing of the skin or eyes).
• Allergic reactions: In rare cases, you might experience hives, itching, swelling, difficulty breathing, or a rapid heartbeat. 
• Gastrointestinal issues: While nausea, diarrhea, and constipation are common and usually mild, if they are severe or persistent, see a doctor immediately. 
• Thyroid tumors: Be alert to a lump or swelling in the neck. Note: A small increased risk has been observed in animal studies, but the risk for humans is considered low.

Are there any long-term risks associated with using GLP-1 medications?

The honest answer? We’re still learning. Long-term studies are ongoing, but current research suggests that GLP-1 medications are generally safe for extended use. As always, talk to your doctor. Your healthcare provider will monitor you regularly to ensure the medication remains safe and effective for you. 

What precautions should be taken while using GLP-1 medications?

Your health is ultimately your responsibility. While using GLP-1 medications, here are some precautions you should take:

• Follow the doctor’s orders: It might sound like a no-brainer, but it’s crucial to take your medication exactly as prescribed. This includes the dosage, timing, and any special instructions from your healthcare provider.
• Stay hydrated: GLP-1 medications can sometimes cause dehydration, especially if you experience nausea or diarrhea. Make sure you’re drinking plenty of water throughout the day.
• Monitor your blood sugar: If you have diabetes, it’s important to check your blood sugar levels regularly as instructed by your doctor. GLP-1 medications can lower blood sugar and, in rare cases, may lead to hypoglycemia (low blood sugar).
• Report any unusual symptoms: If you experience any new or worsening side effects, such as severe abdominal pain, persistent vomiting, or vision changes, let your doctor know right away.

Remember, your healthcare provider is your partner in this journey. Open communication is key to ensuring the safe and effective use of GLP-1 medications.

Can GLP-1 medications interact with other drugs?

Great question! GLP-1 medications can interact with certain other medications, particularly those used to treat diabetes. Here’s what you need to know:

• Be upfront with your healthcare provider: Tell them about ALL medications, supplements, and herbal products you’re taking. Even that daily multivitamin counts!
• Your doctor might need to adjust your medication doses: This is to make sure everything works together safely and effectively.
• You might need monitoring: Your healthcare provider may want to keep a close eye on you to make sure everything’s working as it should.

Remember, knowledge is power (Sounds cliche but it’s true!). The more your healthcare team knows, the better they can help you manage your health.

Exploring GLP-1 medications with Noom

GLP-1 medications offer promising benefits for weight management, blood sugar control, and heart health. These medications can help you feel fuller longer, reduce cravings, and potentially lead to significant weight loss. But remember, these meds work best when you team them up with a healthy lifestyle.

That’s where Noom comes in. We’re not your average diet program—we’re a total mind-body makeover for your eating habits. We dig into the psychology behind why you eat the way you do, teach you about healthier food choices, and help you build habits that stick.

If you qualify, Noom Med takes it a step further, combining medical expertise with Noom’s signature psychological strategies. Here’s what you get:

• A team of qualified clinicians working together to help you reach your weight loss goals.
• A clinician to find the right GLP-1 medication for you, prescribe it, and work with your insurance company on coverage.
• Comprehensive clinical care that works hand-in-hand with Noom’s proven weight loss program.
• Telehealth services and personalized support to keep you on track.

If you’ve already been prescribed a GLP-1, Noom’s GLP-1 Companion program has your back with:

• Nutrition and fitness guidance tailored for GLP-1 users.
• A Muscle Defense™ feature to help you maintain muscle mass.
• A variety of fitness classes like yoga, HIIT, and strength training, all in one app.

With Noom, you’re not just on another diet; you’re adopting a comprehensive approach to weight loss that goes beyond quick fixes and fads. It’s about building lasting habits that set you up for success and support your long-term health and well-being.

Note: Ozempic, Rybelsus, Mounjaro, Victoza, and Trulicity are not FDA-approved to treat obesity or for weight loss.