What you need to know about the side effects of compounded semaglutide

What you’ll learn:

• Compounded semaglutide contains the same active ingredient (semaglutide) as Ozempic^® and Wegovy^®.
• Common side effects of compounded semaglutide can include nausea, vomiting, diarrhea, and constipation, with most symptoms easing as your body adjusts to the medication.
• Noom Med offers compounded semaglutide through Noom GLP-1ᴿˣ, giving you access to an affordable option for weight loss support if prescribed.

If you’ve heard of Ozempic^® or Wegovy^®, then you’re already familiar with semaglutide—both brand-name medications contain it as the active ingredient. These semaglutide medications have been highly effective for people who want to lose weight (off-label for Ozempic^®). The problem is that they can be hard to find due to ongoing shortages and come with a shocking price tag of $1,000 or more per month.

In response to these ongoing issues getting the medication, Noom Med has begun offering our own compounded semaglutide via Noom GLP-1^Rx*. If you qualify, our clinicians can determine if compounded semaglutide is right for you. If your clinician prescribes it, compounded semaglutide will be shipped straight to your door. They’ll guide you through taking the medication, help manage any side effects, and create a care plan that fits your life.

Like any medication, compounded semaglutide can cause some side effects, both mild and potentially more severe. Let’s take a look at what those could be and show you how Noom Med can guide you over any speed bumps on your weight loss journey.

Getting to know Noom GLP-1^Rx compounded semaglutide

Let’s answer some common questions you might have about compounded semaglutide to help you better understand it.

How is compounded semaglutide different from Ozempic^® and Wegovy^®? 

Ozempic^®, Wegovy^®, and compounded semaglutide through Noom GLP-1ᴿˣ contain the same active ingredient and are injectable medications that you take once a week. But, there are a few key differences to be aware of: 

• Taking it will be different: Unlike Ozempic^® and Wegovy^®, which come in preloaded injection pens, Noom GLP-1ᴿˣ provides compounded semaglutide in a vial and syringe. Don’t worry, it’s very easy to use. 
• Lower starting cost: With a starting price of $149 for the first month and $279 per month after that (billed in three-month increments), Noom GLP-1ᴿˣ is more affordable.
• Convenient home delivery: Compounded semaglutide through Noom GLP-1ᴿˣ will be delivered right to your door.
• Access to Noom’s full support: In addition to the medication, you’ll get clinical support through Noom Med and access to the entire Noom Weight program to support you throughout your weight loss journey. 

Why might someone choose Noom GLP-1^Rx compounded semaglutide?

As demand for semaglutide grows, brand-name options can also be hard to find due to shortages. But with Noom GLP-1ᴿˣ, compounded semaglutide is always available, ensuring you get the support you need without delays. It will typically be delivered to your door in seven days or less.

It can also be more affordable if your insurance won’t cover branded medications. While Ozempic^® and Wegovy^® often cost over $1,000 per month without insurance, Noom GLP-1ᴿˣ starts at $149 for the first month. This price includes both the medication, personalized support, and the full Noom weight-loss program.

How can I get compounded semaglutide? 

You can be prescribed compounded semaglutide through Noom GLP-1ᴿˣ if you qualify and your Noom Med clinician determines it’s appropriate for you. 

Common side effects of compounded semaglutide

Let’s talk about what you might experience when taking compounded semaglutide. Keep in mind that most research on side effects focuses on FDA-approved semaglutide products, not compounded versions. But this info can still give you a good idea of what to expect.

What are the most common side effects of taking semaglutide?

Since Noom’s compounded semaglutide shares the same active ingredient as Ozempic^® and Wegovy, you will likely experience similar side effects.

Common side effects associated with semaglutide include:

• Nausea: The most common side effect, with around half of users experiencing it, especially early on.
• Vomiting: Some people may have bouts of vomiting, particularly when starting the medication.
• Diarrhea: Frequent or loose stools can happen as your body adjusts to the treatment.
• Constipation: GLP-1 medications like compounded semaglutide can slow digestion, leading to constipation for some people.
• Headache: Mild to moderate headaches may occur during the initial stages of treatment.
• Injection site reactions: You might notice redness, swelling, or itching where the injection was given.
• Fatigue: Feeling tired is common and could be related to your lowered intake of food, dehydration, and blood sugar variations, 

Most side effects are temporary. As your body adjusts to the medication, you’ll likely notice these effects becoming less bothersome. But everyone’s experience is different, so don’t worry if it takes a bit longer for you.

When should you consult your clinician about side effects?

Always feel free to reach out to your clinician if side effects are concerning, don’t improve over time, or interfere with your daily life. Also, seek immediate medical attention if you experience signs of an allergic reaction or severe stomach pain. Your health and comfort are important, so don’t hesitate to reach out to your clinician with any concerns.

Important considerations and risk factors

Semaglutide offers a promising path to weight loss, but potential risks and long-term effects should be considered before starting this medication. Let’s address some key questions you might have so you can make an informed decision about your health.

What are the serious side effects and warnings associated with semaglutide?

While generally well-tolerated, semaglutide can potentially lead to more serious side effects in some individuals. Get immediate medical attention if you experience any signs of the following conditions:

• Gallbladder problems: Semaglutide may increase the risk of gallstones or inflammation of the gallbladder. Symptoms can include severe pain in the upper right abdomen, fever, nausea, and vomiting.  
• Pancreatitis: In rare cases, semaglutide has been linked to pancreatitis, a serious inflammation of the pancreas. You might experience intense abdominal pain, nausea, vomiting, and fever.  
• Low blood sugar (hypoglycemia): Low blood sugar can occur when combining semaglutide with other blood sugar-lowering diabetes drugs. Be alert for shakiness, sweating, dizziness, confusion, and rapid heartbeat.  
• Kidney problems: While rare, dehydration experienced with semaglutide may affect kidney function, particularly in individuals with pre-existing kidney conditions. Symptoms to watch for include changes in urination, swelling in the legs or ankles, fatigue, or shortness of breath.  
• Allergic reactions: Though uncommon, severe allergic reactions can occur, requiring immediate medical attention. You might experience hives, itching, swelling, and difficulty breathing.  

While these serious side effects are uncommon with both compounded and brand-name semaglutide, it’s important to familiarize yourself with the signs and symptoms. 

What risk factors increase the likelihood of serious side effects?

Several factors can increase the likelihood of experiencing serious side effects from semaglutide, both in compounded and brand-name forms:

• Thyroid cancer history: People with a personal or family history of medullary thyroid carcinoma (MTC) shouldn’t use semaglutide or other GLP-1s due to a slightly increased risk of this type of cancer.
• Pancreatitis: If you’ve had pancreatitis before, semaglutide or GLP-1 medications may increase your risk of inflammation in the pancreas, so you shouldn’t take them.
• Digestive issues: Those with severe gastrointestinal problems may see their symptoms worsen with GLP-1s like semaglutide.
• Allergies: Avoid branded and compounded versions if you’re allergic to GLP-1 medications or their ingredients.
• Pregnancy or breastfeeding: GLP-1 medications aren’t safe for use during pregnancy or while breastfeeding.
• Other conditions: If you have kidney or liver disease, talk to your doctor before starting a GLP-1, as you may need monitoring.

Managing and minimizing side effects

Dealing with side effects can be challenging, but there are ways to make your experience with compounded semaglutide more comfortable. Here are some tips to help you manage common side effects:

• Start small: Your clinician will start you on the lowest dose and gradually increase it. This can help your body adjust and potentially reduce side effects.
• Eat mindfully: Try smaller, more frequent meals instead of large ones. This can help with nausea and digestive issues.
• Stay hydrated: Drink plenty of water throughout the day to combat constipation and help your body process the medication.

• Get moving: Light exercise, like a short walk after meals, can aid digestion and help manage blood sugar levels. 
• Rest up: Make sure you’re getting enough sleep to combat fatigue, which is a common side effect.
• Track your symptoms: Keep a log of when side effects occur and what triggers them. This can help you and your clinician make informed decisions about your treatment.

Noom’s GLP-1 Companion can also be a valuable tool in managing side effects and staying on track with your weight loss goals. This program offers personalized guidance on protein intake, overcoming common challenges, and setting yourself up for success.

The GLP-1 Companion includes features like:

• A protein tracker to help you boost intake to prevent muscle loss. 
• A Muscle Defense™ library with exercises to help you build and maintain muscle mass
• Lessons to guide you through your weight loss journey
• Your “Success kit” will also contain additional side effect support.

Remember, everyone’s experience with compounded semaglutide is unique. What works for one person might not work for another. Always stay in touch with your clinician and adjust your approach as needed. With the right support and strategies, you can manage side effects and focus on your health goals.

Compounded semaglutide and Noom 

Understanding the potential side effects of compounded semaglutide is essential, but making informed decisions about your health journey doesn’t stop there. That’s where Noom can be your trusted partner.

Noom is a comprehensive program that goes beyond just tracking calories and exercise. We dive into the psychology of eating, helping you understand your habits and triggers—equipping you with tools to make lasting changes. Our holistic approach addresses both the physical and mental aspects of health for sustainable weight loss. By focusing on your behaviors and mindset, Noom can also support you in gradually tapering off medications like GLP-1, reducing the risk of regaining weight as you transition to a more self-driven plan. 

Whether considering compounded semaglutide or seeking a comprehensive approach to weight loss, Noom provides the knowledge and support you need to achieve your goals.

*Compounded semaglutide available on the Noom platform is produced in an FDA-registered facility but not reviewed by the FDA for safety, efficacy, or quality.

Not all customers will medically qualify for prescription medications. Medications are only available when clinically indicated.

Note: Ozempic^® is not FDA-approved to treat obesity or for weight loss.